Racial heterogeneity of IgA1 hinge-region O-glycoforms in patients with IgA nephropathy

Racial heterogeneity of IgA1 hinge-region O-glycoforms in patients with IgA nephropathy

Blog Article

Summary: Galactose (Gal)-deficient IgA1 (Gd-IgA1) is involved in IgA nephropathy (IgAN) pathogenesis.To reflect racial differences in clinical characteristics, we assessed disease- and race-specific heterogeneity in the O-glycosylation of the IgA1 hinge region (HR).We determined serum Gd-IgA1 levels in Caucasians (healthy controls [HCs], n = 31; IgAN here patients, n = 63) and Asians (HCs, n = 20; IgAN patients, n = 60) and analyzed profiles of serum IgA1 HR O-glycoforms.Elevated serum Gd-IgA1 levels and reduced number of Gal residues per HR were observed in Caucasians.

Reduced number of N-acetylgalactosamine (GalNAc) residues per HR and elevated relative abundance of IgA1 with three HR O-glycans were acure face lotion common features in IgAN patients; these features were associated with elevated blood pressure and reduced renal function.We speculate that the mechanisms underlying the reduced GalNAc content in IgA1 HR may be relevant to IgAN pathogenesis.